The Curse of Dethklok is a phenomenon which directly or indirectly injures, mutilates, and/or kills various people who associate with the band Dethklok.

The main people affected by this curse are Dethklok fans, the Klokateers/Dethklok Employees (This is confirmed when in an instructional video facebones states that "Death is a part of the everyday workplace, if you see someone dead, don't freak out, just, ring your deathbell!"), business associates, Tribunal personnel/assassins/spies, and Dethklok's enemies/antagonists.

Some characters such as Dethklok manager Charles Foster Ofdensen, Dr. Rockzo, as well as some Dethklok family members (and even Dethklok members themselves) appear to be immune to it or aren't affected by it despite repeated contact with the band.

The Curse of Dethklok is believed to be related to the Metalocalyse and possibly the reason The Tribunal monitors them closely. The members of Dethklok are mostly unaware of the phenomenon (or are used to it). Dethklok is shown to be somewhat aware of a possible curse, as they all agree their Chefs are cursed in the episode The Curse of Dethklok.

The curse itself seems to be a mundane occurrence in the daily lives of the band members, and appears to have affected people around them even before Dethklok was formed: in a flashback in the episode Dethgov, a young Nathan watches as his classmates & teacher die after a drunken redneck (who was shot by the cops chasing him) crashes his pickup truck into Nathan's classroom; in the episode Performance Klok, an infant William Murderface watches his father murder his mother with a chainsaw, then turn the chainsaw on himself, leaving him to be raised by his grandparents. Toki Wartooth is the only Dethklok member who seems to be negatively affected by the curse, resulting in the deaths of his father and people he had befriended (one example being Little Julliette Sarmangsadandle).

It should be noted not all of those effected by the curse die, but horribly mutilated/injured instead (with some being cybernetical enhanceed):

• Chef Jean-Pierre - The chef was hit by a stray firework missile and chopped to pieces by helicopter blades; he somehow survived thanks to life support machines, and was sewn back together with limited success.
• Dick "Magic Ears" Knubbler - Eyes explode due to extreme change in water pressure, which are later replaced with a pair of cybernetic eyes.
• Dr. Johnathan Twinkletits - Survived a fall and had his arms ripped off by Yard Wolves, which were later replaced with cybernetic arms.
• Rebecca Nightrod - Fell down a flight of very long stairs, ended up in a coma.
• Dethklok Minute Host - Burned by flames after a meteor crashed into the Dethklok Minute studio leaving his face disfigured.